A sensitive assay reveals structural requirements for α-synuclein fibril growth
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چکیده
منابع مشابه
A sensitive assay reveals structural requirements for α-synuclein fibril growth.
The accumulation of α-synuclein (α-syn) fibrils in neuronal inclusions is the defining pathological process in Parkinson's disease (PD). A pathogenic role for α-syn fibril accumulation is supported by the identification of dominantly inherited α-syn (SNCA) gene mutations in rare cases of familial PD. Fibril formation involves a spontaneous nucleation event in which soluble α-syn monomers associ...
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3 4 Thibault Viennet, Michael M. Wördehoff, Boran Uluca, Chetan Poojari, Hamed 5 Shaykhalishahi, Dieter Willbold, Birgit Strodel, Henrike Heise, Alexander K. Buell, 6 Wolfgang Hoyer, Manuel Etzkorn 7 8 Institute of Physical Biology, Heinrich-Heine-University Düsseldorf, Germany 9 Instititue of Complex Systems, Forschungszentrum Jülich, Germany 10 Department of Physics, Tampere University of Tec...
متن کاملStructural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.
We describe the isolation and detailed structural characterization of stable toxic oligomers of α-synuclein that have accumulated during the process of amyloid formation. Our approach has allowed us to identify distinct subgroups of oligomers and to probe their molecular architectures by using cryo-electron microscopy (cryoEM) image reconstruction techniques. Although the oligomers exist in a r...
متن کاملCorrigendum: Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth
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متن کاملDirect Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth
Aggregation of proteins into amyloid deposits is the hallmark of several neurodegenerative diseases such as Alzheimer's and Parkinson's disease. The suggestion that intermediate oligomeric species may be cytotoxic has led to intensified investigations of pre-fibrillar oligomers, which are complicated by their transient nature and low population. Here we investigate alpha-synuclein oligomers, en...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2017
ISSN: 0021-9258
DOI: 10.1074/jbc.m116.767053